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Posted: September 7th, 2022
Aging and Telomeres
Question Assignment 1.
Telomere-based getting old is non-stochastic. Telomeres are discovered on the finish of the chromosomes and are tasked with defending the DNA as soon as cells divide. Upon this division, solely the DNA is replicated into the brand new cell, whereas telomeres should not. In line with Wang et al. (2018), the latter are shortened to the purpose of their breakdown, so the method of the DNA copying stops. Due to this fact, such a shortening results in getting old and loss of life.
Question Assignment 2.
Telomere-based getting old could be categorised as programmed concept. Such a concept stipulates that getting old is an already programmed course of dictated by genetics that happens over time, which implies it’s time-based (Lange & Grossman, 2018). The speculation helps show the telomere-based getting old course of since when cells cease dividing to create new ones, tissues subsequently turn into broken since outdated cells should not changed. Thus, the shortened telomeres are the causes of such situations as despair, hypertension, cardiovascular illnesses, weight problems, and osteoporosis.
Question Assignment three.
As a gerontological researcher, I’d discover methods of stopping telomeres from shortening. In line with DePinho, this purpose could be achieved primarily by reawakening the telomerase enzyme within the particular cells the place it isn’t current or the place it has stopped working (Callaway, 2010). Thus, these telomeres cease shortening and subsequently dying, which kills the cells ultimately. As soon as the enzyme is reactivated, the identical course of happens to the cells are, which may finally result in the prevention of telomeres shortening. In different phrases, scientist can stop ageing. Manipulating the telomerase enzyme helps halt the shortening course of. Due to this fact, as soon as this course of stops, it’s potential to sluggish getting old and keep away from premature loss of life (Wang et al., 2018). The invention of tips on how to stop the shortening in telomeres could be an unimaginable scientific achievement and an enormous contribution to the scientific neighborhood as a result of individuals would be capable of reside longer. Lastly, eliminating genetic-related illnesses will probably be simpler, which can even be a reduction for the well being care system.
References
Callaway, E. (2010). Telomerase reverses the getting old course of. Nature. https://doi.org/10.1038/information.2010.635
Lange, J., & Grossman, S. (2018). Theories of getting old. In Okay. Mauk (Ed.), Gerontological nursing competencies for care (four ed., pp. 41-58). Jones & Bartlett Studying.
Wang, Q., Zhan, Y., Pedersen, N. L., Fang, F., & Hägg, S. (2018). Telomere size and all-cause mortality: A meta-analysis. Aging Analysis Assessments, 48, 11-20. https://doi.org/10.1016/j.arr.2018.09.002
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