Posted: September 21st, 2022

GCU NUR 641E Topic 7: Neurological, Musculoskeletal,

GCU NUR 641E Topic 7: Neurological, Musculoskeletal, And Integumentary System: Chosen Pathophysiology And Pharmacologic Remedy
GCU NUR 641E Topic 7: Neurological, Musculoskeletal, And Integumentary System: Chosen Pathophysiology And Pharmacologic Remedy

Topic 7 DQ 1

Apr 14-16, 2022

Select a medical situation from the neurological, musculoskeletal, or integumentary system and clarify the pathophysiology modifications which will happen. What affected person schooling would must be included associated to this dysfunction? Just remember to choose a unique medical situation than your friends. Embody the identify of the medical situation within the topic line in order that the medical situation will be adopted. Embody your references in APA type.

Replies to w

Levodopa (L-Dopa)

Levodopa is a dopamine precursor; it’s useful for controlling bradykinetic signs related to Parkinson’s illness (PD) and bettering the standard of life in individuals with idiopathic PD (Gandhi KR, 2021). Levodopa could halt the course of Parkinson’s illness or present additional benefits lengthy after the drugs is stopped.

Mechanism of Motion

Levodopa is transformed to dopamine in each the CNS and the periphery. Inhibitors of dopamine decarboxylase forestall Levodopa from being transformed to dopamine within the periphery, permitting extra Levodopa to penetrate the Blood-Mind Barrier (Gandhi KR, 2021). As soon as transformed to dopamine, it acts on postsynaptic dopaminergic receptors, compensating for the lack of endogenous dopamine.

Hints for monitoring

People on Levodopa should periodically check their BUN, creatinine, and hepatic operate (Gandhi KR, 2021). (Gandhi KR, 2021). Levodopa customers should keep a wholesome liver as a result of it’s the place the drug is decarboxylated. It’s additionally essential to evaluate the intraocular strain of somebody with glaucoma to verify it’s secure. It’s essential to watch peripheral neuropathy each earlier than and after utilizing levodopa to see whether or not it can worsen. Moreover, sufferers ought to have common dyskinesia checks. Due to this fact, it’s essential to look at sufferers who take dopaminergic drugs for psychotic conduct and hallucinations. Hallucinations can occur when persons are confused or have many desires.

Unwanted effects

Taking Levodopa’s most typical uncomfortable side effects are nausea, dizziness, headache, and sleepiness. Typical uncomfortable side effects for older individuals who take Levodopa are confusion, hallucinations, delusions, psychosis, and agitation.

Drug interactions

Levodopa is contraindicated when monoamine oxidase inhibitors (MAOIs) are used concurrently, as this may end in a hypertensive disaster (Gandhi KR, 2021). Nonetheless, when transitioning from Levodopa to an MAOI or vice versa, a 14-day washout interval needs to be noticed. Sufferers utilizing D2 antagonists could lower the consequences of Levodopa, which can reduce the drug’s optimistic advantages (Gandhi KR, 2021).

Reference:

Gandhi KR, S. A. (2021, April 30). Levodopa (L-dopa) – StatPearls – NCBI bookshelf. Nationwide Heart for Biotechnology Info. https://www.ncbi.nlm.nih.gov/books/NBK482140/

Topic 7: Neurological, Musculoskeletal, And Integumentary System: Chosen Pathophysiology And Pharmacologic Remedy
Apr 14-20, 2022

Max Factors:30

Targets:

Describe regular pathophysiology and alterations within the pathophysiology of neurological issues, musculoskeletal, and integumentary system issues.
Combine data of pathophysiology and pharmacology into instructing and academic supplies in various settings.
Describe a pharmacological intervention utilizing an evidence-based therapy guideline.
Topic eight: Endocrine System: Chosen Pathophysiology And Pharmacologic Remedy
Apr 21-27, 2022

Max Factors:180

Targets:

Describe regular pathophysiology and alterations of the endocrine system.
Combine data of pathophysiology and pharmacology into instructing and academic supplies in various settings.
Describe a pharmacological intervention utilizing an evidence-based therapy guideline.

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