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Posted: September 9th, 2022
Aging and Telomeres
Aging and Telomeres
Question Assignment 1.
Telomere-based getting older is non-stochastic. Telomeres are discovered on the finish of the chromosomes and are tasked with defending the DNA as soon as cells divide. Upon this division, solely the DNA is replicated into the brand new cell, whereas telomeres will not be. In line with Wang et al. (2018), the latter are shortened to the purpose of their breakdown, so the method of the DNA copying stops. Subsequently, such a shortening results in getting older and demise.
Question Assignment 2.
Telomere-based getting older may be categorised as programmed concept. Such a concept stipulates that getting older is an already programmed course of dictated by genetics that happens over time, which implies it’s time-based (Lange & Grossman, 2018). The idea helps show the telomere-based getting older course of since when cells cease dividing to create new ones, tissues subsequently turn out to be broken since previous cells will not be changed. Thus, the shortened telomeres are the causes of such situations as despair, hypertension, cardiovascular illnesses, weight problems, and osteoporosis.
Question Assignment three.
As a gerontological researcher, I’d discover methods of stopping telomeres from shortening. In line with DePinho, this aim may be achieved primarily by reawakening the telomerase enzyme within the particular cells the place it’s not current or the place it has stopped working (Callaway, 2010). Thus, these telomeres cease shortening and subsequently dying, which kills the cells ultimately. As soon as the enzyme is reactivated, the identical course of happens to the cells are, which might in the end result in the prevention of telomeres shortening. In different phrases, scientist can stop ageing. Manipulating the telomerase enzyme helps halt the shortening course of. Subsequently, as soon as this course of stops, it’s doable to sluggish getting older and keep away from premature demise (Wang et al., 2018). The invention of how you can stop the shortening in telomeres could be an unbelievable scientific achievement and an enormous contribution to the scientific neighborhood as a result of individuals would be capable of stay longer. Lastly, eliminating genetic-related illnesses will likely be simpler, which may also be a reduction for the well being care system.
References
Callaway, E. (2010). Telomerase reverses the getting older course of. Nature. https://doi.org/10.1038/information.2010.635
Lange, J., & Grossman, S. (2018). Theories of getting older. In Ok. Mauk (Ed.), Gerontological nursing competencies for care (four ed., pp. 41-58). Jones & Bartlett Studying.
Wang, Q., Zhan, Y., Pedersen, N. L., Fang, F., & Hägg, S. (2018). Telomere size and all-cause mortality: A meta-analysis. Aging Analysis Critiques, 48, 11-20. https://doi.org/10.1016/j.arr.2018.09.002
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